496 A microbial supply chain for production of the anti-cancer drug vinblastine.
https://www.nature.com/articles/s41586-022-05157-3
495 Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor.
https://www.science.org/doi/10.1126/scitranslmed.abn0449
494 Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris.
https://www.pnas.org/doi/10.1073/pnas.2201711119
493 New intranasal and injectable gene therapy for healthy life extension.
https://www.pnas.org/doi/10.1073/pnas.2121499119
492 A tissue-like neurotransmitter sensor for the brain and gut.
https://www.nature.com/articles/s41586-022-04615-2
491 Production of β-ketoadipic acid from glucose in Pseudomonas putida KT2440 for use in performance-advantaged nylons.
https://www.sciencedirect.com/science/article/pii/S266638642200114X?via%3Dihub
490 Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy.
https://www.science.org/doi/10.1126/sciadv.abm8011
489 Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a Bleomycin-Induced Murine Model.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202270108
488 Spherical nucleic acids as an infectious disease vaccine platform.
https://www.pnas.org/doi/10.1073/pnas.2119093119
487 Large scale production of synthetic spider silk proteins in Escherichia coli.
https://www.sciencedirect.com/science/article/abs/pii/S104659282100022X
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