25 Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Possemato R. et al. (2011). Nature 476:346-350.
http://www.nature.com/nature/journal/v476/n7360/full/nature10350.html
24 Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases.(Review). Nakamura T and Lipton SA. (2011). Cell Death and Differentiation 18: 1478–1486.
http://www.nature.com/cdd/journal/v18/n9/abs/cdd201165a.html
23 A screen identifies a drug that specifically kills glycolysis-dependent cancer cells by inhibiting glucose uptake. Chan DA. (2011). Sci Transl Med 3:p. 94ra70
http://stm.sciencemag.org/content/3/94/94ra70.abstract
22 Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Sievers SA. et al. (2011). Nature 475:96-100.
http://www.nature.com/nature/journal/v475/n7354/full/nature10154.html
21 Ablation of a gene controlling fat breakdown can protect mice from cancer-associated uncontrolled loss of fat and muscle. Das SK. et al. (2011). Science 333: 233-238.
http://www.sciencemag.org/content/333/6039/233.abstract
20 MicroRNAs 103 and 107 regulate insulin sensitivity. Trajkovsky M. et al. (2011). Nature 474:649-653.
http://www.nature.com/nature/journal/v474/n7353/full/nature10112.html
19 A Key Enzyme in the Biogenesis of Lysosomes Is a Protease That Regulates Cholesterol Metabolism. Marschner K. et al. (2011). Science 333:87-90.
http://www.sciencemag.org/content/333/6038/87.abstract
18 N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Lucanic M. et al. (2011). Nature 473: 226-229.
http://www.nature.com/nature/journal/v473/n7346/full/nature10007.html
17 Anchored clathrate waters bind antifreeze proteins to ice. Garnham CP. et al. (2011). PNAS 108:7363-7367.
http://www.pnas.org/content/108/18/7363
16 Metabolite profiles and the risk of developing diabetes. Five branched-chain and aromatic amino acids had highly significant associations with future diabetes: isoleucine, leucine, valine, tyrosine and phenylalanine. Wang TJ et al. (2011). Nature Medicine 17:448–453.
http://www.nature.com/nm/journal/v17/n4/abs/nm.2307.html
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