284 In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.
https://www.nature.com/articles/s41586-021-03534-y
283 Discovery, characterization and engineering of ligases for amide synthesis.
https://www.nature.com/articles/s41586-021-03447-w
282 High CO2 levels drive the TCA cycle backwards towards autotrophy.
https://www.nature.com/articles/s41586-021-03456-9
281 Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal.
https://www.pnas.org/content/118/15/e2103090118
280 X-ray crystal structures reveal how anticoagulants inhibit a vitamin K regenerating enzyme.
https://science.sciencemag.org/content/371/6524/eabc5667
279 Prebiotic synthesis of cysteine peptides that catalyze peptide ligation in neutral water.
https://science.sciencemag.org/content/370/6518/865
278 Serine restriction alters sphingolipid diversity to constrain tumour growth.
https://www.nature.com/articles/s41586-020-2609-x
277 Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose.
https://science.sciencemag.org/content/370/6514/314
276 Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.
https://science.sciencemag.org/content/370/6514/eaay8085
275 How cholesterol stiffens unsaturated lipid membranes.
https://www.pnas.org/content/117/36/21896
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