232 The plasma membrane lipid sphingomyelin has two distinct conformations depending on the presence or absence of cholesterol.
https://www.cell.com/cell/fulltext/S0092-8674(18)31656-8
231 The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species.
https://www.nature.com/articles/s41467-019-08555-w
230 Redox and pH gradients drive amino acid synthesis in iron oxyhydroxide mineral systems.
https://www.pnas.org/content/early/2019/02/19/1812098116
229 Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
https://www.nature.com/articles/s41586-019-0904-1
228 The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis.
https://www.nature.com/articles/s41586-019-0920-1
227 Using a make-on-demand library that contains hundreds-of-millions of molecules, structure-based docking was used to identify compounds that, after synthesis and testing, are shown to interact with AmpC β-lactamase and the D4 dopamine receptor with high affinity.
https://www.nature.com/articles/s41586-019-0917-9
226 Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
https://www.nature.com/articles/s41467-018-08008-w
225 Two-step pathway for isoprenoid synthesis.
https://www.pnas.org/content/116/2/506
224 Dietary sugar silences a colonization factor in a mammalian gut symbiont.
https://www.pnas.org/content/116/1/233
223 Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
https://www.nature.com/articles/s41586-018-0749-z
|
