7 Repeated vaccination of mice with bacille Calmette-Guérin after Mycobacteriun infection results in increased IL-17, tumor necrosis factor, IL-6, and MIP-2 expression, influx of granulocytes/neutrophils, and lung tissue damage.
Cruz et al. (2010). J. Exp Med. 207:1609-1616.
http://jem.rupress.org/content/207/8/1609.abstract
6 Peroxisome proliferator–activated receptors (PPAR-δ) serves as an important molecular brake for the control of autoimmune inflammation. Dunn et al. (2010). J. Exp Med. 207:1599-1608.
http://jem.rupress.org/content/207/8/1599.abstract
5 Mature B cell depletion using a CD20-specific monoclonal antibody induces a significant reduction of atherosclerosis in various mouse models of the disease. Ait-Oufella et al. (2010). J. Exp. Med. 207: 1579-1587.
http://jem.rupress.org/content/207/8/1579.abstract
4 Low-dose IL-2 can reverse established Type 1 diabetes in a mouse model. Grinberg-Bleyer et al., J. Exp. Med. (2010) (in press)
http://jem.rupress.org/content/early/2010/07/28/jem.20100209.abstract
3 A transcription factor Bcl11b is essential for maintenance of T cell identity.
Li et al. (2010). Science 329: 89-93.
http://www.sciencemag.org/cgi/content/full/329/5987/89
2 An immunotolerant microenvironment driven by chemokine expression contributes to tumor growth and spread.
Shields J.D. et al (2010) Science 328, 749-752
http://scienceonline.org/cgi/content/abstract/328/5979/749
1 Patients with HIV are prone to life-threatening Salmonella infections, thought to be a result of HIV hijacking cellular immunity. HIV-infected serum contains high levels of an antibody that binds lipopolysaccharide molecules in the bacteria's outer membrane, inhibiting the normal destruction of Salmonella by the immune system. MacLennan et al. (2010) Science 328, 508-512.
http://www.sciencemag.org/cgi/content/abstract/328/5977/508
|
