1468 Development of A10P3C, an isoform-selective inhibitor of EGLN2, for targeting breast cancer
https://www.pnas.org/doi/10.1073/pnas.2613915123
1467 Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansion
https://www.science.org/doi/10.1126/science.aed3065
1466 Membranolytic peptide programs immunogenic cell death for cancer therapy
https://www.nature.com/articles/s41586-026-10899-5
1465 Key regulatory elements of the TGFβ–LRRC15 axis predict disease progression and immunotherapy resistance across cancer types
https://www.pnas.org/doi/10.1073/pnas.2500524123
1464 Ceramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program
https://www.science.org/doi/10.1126/science.adw8520
1463 A tumour-derived organoid biobank maps cancer gene dependencies
https://www.nature.com/articles/s41586-026-10830-y
1462 Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer
https://www.cell.com/cell/abstract/S0092-8674(26)00826-3
1461 A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death
https://www.cell.com/cell/abstract/S0092-8674(26)00757-9
1460 Reprogramming engineered autologous T cells to overcome resistance in patients with Merkel cell carcinoma
https://www.science.org/doi/10.1126/scitranslmed.aea8773
1459 Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis
https://www.science.org/doi/10.1126/science.aea4287
1458 TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer
https://www.nature.com/articles/s41586-026-10705-2
1457 Loss of Sox10 prevents tumor initiation in vivo and induces luminal-to-basal reprogramming in Neu+ tumor cells
https://www.pnas.org/doi/10.1073/pnas.2520063123
1456 Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle
https://www.science.org/doi/10.1126/science.adv8291
1455 Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
https://www.nature.com/articles/s41586-026-10613-5
1454 mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity
https://www.pnas.org/doi/10.1073/pnas.2525718123
1453 Farnesylation-driven KRAS phase separation promotes colon tumor growth
https://www.cell.com/cell/abstract/S0092-8674(26)00519-2
1452 AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology
https://www.cell.com/cell/abstract/S0092-8674(26)00458-7
1451 Lysosomal TMEM165 remodels calcium signaling to drive hypoxia adaptation and tumor progression
https://www.pnas.org/doi/10.1073/pnas.2532309123
1450 Biodiversity and biogeography of the multi-kingdom cancer microbiome
https://www.cell.com/cell/abstract/S0092-8674(26)00440-X
1449 Electronic cigarette use after smoking cessation and lung cancer risk
https://www.nature.com/articles/s41591-026-04469-5
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