Cancer Biology

 
1228 A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
https://stm.sciencemag.org/content/13/603/eabf1383

1227 Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels.
https://www.pnas.org/content/118/29/e2023868118

1226 Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
https://stm.sciencemag.org/content/13/602/eaba4627

1225 Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade.
https://stm.sciencemag.org/content/13/602/eabb3631

1224 Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment.
https://www.pnas.org/content/118/28/e2101169118

1223 A nanovaccine based on bacterial cytoplasmic membranes and cell membranes from resected tumor tissue prevents tumor recurrence in mice.
https://stm.sciencemag.org/content/13/601/eabc2816

1222 Down-regulation of A20 promotes immune escape of lung adenocarcinomas.
https://stm.sciencemag.org/content/13/601/eabc3911

1221 Initiation and progression of leukemogenesis in Down syndrome involves distinct cellular origins and effects of trisomy 21.
https://science.sciencemag.org/content/373/6551/eabf6202

1220 Li et al. identify LIMIT as a lncRNA that modulates MHC-I expression through HSP90 and HSF1, thereby regulating antitumour immune response and the efficacy of immunotherapy.
https://www.nature.com/articles/s41556-021-00672-3

1219 AI-based pathology predicts origins for cancers of unknown primary.
https://www.nature.com/articles/s41586-021-03512-4

1218 Treatment with a specific inhibitor of the N6-methyladenosine methyltransferase METTL3 leads to reduced growth of cancer cells, indicating the potential of approaches targeting RNA-modifying enzymes for anticancer therapy.
https://www.nature.com/articles/s41586-021-03536-w

1217 Positron emission tomography measurements of nutrient uptake in cells of the tumour microenvironment reveal cell-intrinsic partitioning in which glucose uptake is higher in myeloid cells, whereas glutamine is preferentially acquired by cancer cells.
https://www.nature.com/articles/s41586-021-03442-1

1216 Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
https://www.pnas.org/content/118/19/e2020490118

1215 Platinum(II) N-heterocyclic carbene complexes arrest metastatic tumor growth.
https://www.pnas.org/content/118/17/e2025806118

1214 Combining IL-15 superagonist and anti-GITR agonist therapy enhances antitumor effects of radiation therapy in a mouse model of mesothelioma.
https://stm.sciencemag.org/content/13/589/eabd9882

1213 A phase 1 clinical trial provides evidence that a vaccine against mutant IDH1 is safe and produces a T helper immune response in patients with glioma.
https://www.nature.com/articles/s41586-021-03363-z

1212 Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma.
https://www.pnas.org/content/118/15/e2013598118

1211 Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.
https://www.nature.com/articles/s41556-021-00644-7

1210 Mitochondrial copper depletion suppresses triple-negative breast cancer in mice.
https://www.nature.com/articles/s41587-020-0707-9

1209 Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression.
https://stke.sciencemag.org/content/14/677/eaax5971

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