Orthopedics

Articles:
86 A self-powered implantable and bioresorbable electrostimulation device for biofeedback bone fracture healing.
https://www.pnas.org/content/118/28/e2100772118

85 Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis.
https://stm.sciencemag.org/content/13/580/eaau8491

84 Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits.
https://www.pnas.org/content/117/46/28655

83 In situ bone regeneration of large cranial defects using synthetic ceramic implants with a tailored composition and design.
https://www.pnas.org/content/117/43/26660

82 Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity.
https://stm.sciencemag.org/content/12/567/eaan7967

81 ROR2 blockade improves the functional and structural outcomes of osteoarthritis in preclinical animal models by inhibiting YAP signaling.
https://stm.sciencemag.org/content/12/561/eaax3063

80 Agrin heals joint surfaces by recruiting joint stem cells and inducing the formation of cartilage and bone with correct architecture in mice and sheep.
https://stm.sciencemag.org/content/12/559/eaax9086

79 Regenerative peripheral nerve interfaces show promise to improve prosthetic rehabilitation in people with upper limb loss.
https://stm.sciencemag.org/content/12/533/eaay2857

78 JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.
https://stm.sciencemag.org/content/12/530/eaay4447

77 Oxytocin regulates body composition.
https://www.pnas.org/content/116/52/26808

76 Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE).
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32489-4/fulltext

75 Study shows the repair of enamel via a biomimetic growth frontier that is constructed from calcium phosphate ion clusters.
https://advances.sciencemag.org/content/5/8/eaaw9569

74 Locally renewing resident synovial macrophages provide a protective barrier for the joint.
https://www.nature.com/articles/s41586-019-1471-1

73 Prominent exostosis projecting from the occipital squama more substantial and prevalent in young adult than older age groups.
https://www.nature.com/articles/s41598-018-21625-1

72 A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
https://stm.sciencemag.org/content/11/489/eaar4953

71 Biomaterials-aided mandibular reconstruction using in vivo bioreactors.
https://www.pnas.org/content/116/14/6954

70 Oral versus Intravenous Antibiotics for Bone and Joint Infection.
https://www.nejm.org/doi/full/10.1056/NEJMoa1710926

69 Increased glutamine metabolism caused by unregulated HIF-1α signalling in mouse chondrocytes results in increased post-translational modification of collagen and skeletal dysplasia, demonstrating that strict regulation of HIF-1α signalling in chondrocytes is essential for normal bone growth.
https://www.nature.com/articles/s41586-019-0874-3

68 Deep neural network improves fracture detection by clinicians.
http://www.pnas.org/content/115/45/11591

67 ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.
http://stm.sciencemag.org/content/10/458/eaar8426

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