93 An aged immune system drives senescence and ageing of solid organs.

92 In aged mice, inhibition of prostaglandin E2 (PGE2) signalling through its receptor EP2 improves cellular bioenergetics, reduces inflammatory responses and restores hippocampal plasticity to youthful levels, resulting in an improvement in spatial memory and cognition.

91 Increased activity of prostaglandin E2 in older mice helps restore lost muscle.

90 Inactivation of the histone acetyltransferase gene KAT7 prolongs survival in naturally aged mice and progeroid mice that age prematurely.

89 Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight.

88 Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.

87 Ageing hallmarks exhibit organ-specific temporal signatures.

86 Bacteria-derived metabolite, methylglyoxal, modulates the longevity of C. elegans through TORC2/SGK-1/DAF-16 signaling.

85 Clues to the aging process are derived from analysis of single yeast cells throughout their life span.

84 Physiological blood–brain transport is impaired with age by a shift in transcytosis.

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