Physiology

Articles:

93 An aged immune system drives senescence and ageing of solid organs.
https://www.nature.com/articles/s41586-021-03547-7

92 In aged mice, inhibition of prostaglandin E2 (PGE2) signalling through its receptor EP2 improves cellular bioenergetics, reduces inflammatory responses and restores hippocampal plasticity to youthful levels, resulting in an improvement in spatial memory and cognition.
https://www.nature.com/articles/s41586-020-03160-0

91 Increased activity of prostaglandin E2 in older mice helps restore lost muscle.
https://science.sciencemag.org/content/371/6528/eabc8059

90 Inactivation of the histone acetyltransferase gene KAT7 prolongs survival in naturally aged mice and progeroid mice that age prematurely.
https://stm.sciencemag.org/content/13/575/eabd2655

89 Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight.
https://www.pnas.org/content/117/38/23942

88 Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.
https://advances.sciencemag.org/content/6/32/eaba1306

87 Ageing hallmarks exhibit organ-specific temporal signatures.
https://www.nature.com/articles/s41586-020-2499-y

86 Bacteria-derived metabolite, methylglyoxal, modulates the longevity of C. elegans through TORC2/SGK-1/DAF-16 signaling.
https://www.pnas.org/content/117/29/17142

85 Clues to the aging process are derived from analysis of single yeast cells throughout their life span.
https://science.sciencemag.org/content/369/6501/325

84 Physiological blood–brain transport is impaired with age by a shift in transcytosis.
https://www.nature.com/articles/s41586-020-2453-z

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