Structural Biology

Articles:
163 Geometric deep learning of RNA structure.
http://science.sciencemag.org/content/373/6558/1047

162 Computational design of a synthetic PD-1 agonist.
https://www.pnas.org/content/118/29/e2102164118

161 Structural basis of omega-3 fatty acid transport across the blood–brain barrier.
https://www.nature.com/articles/s41586-021-03650-9

160 A structure of RNA polymerase II in complex with spliceosomal particle U1 snRNP reveals how transcription and RNA splicing are coupled.
https://science.sciencemag.org/content/371/6526/305

159 Structures of the iron transporter ferroportin and the peptide hormone hepcidin suggest how iron homeostasis is tightly regulated.
https://www.nature.com/articles/s41586-020-2668-z

158 Computational design of transmembrane pores.
https://www.nature.com/articles/s41586-020-2646-5

157 Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
https://www.nature.com/articles/s41586-020-2357-y

156 A mass spectrometry analysis reveals the glycan composition at all glycosylation sites on the SARS-CoV-2 spike protein.
https://science.sciencemag.org/content/369/6501/330

155 Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
https://science.sciencemag.org/content/368/6492/779

154 The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage.
https://www.pnas.org/content/117/19/10254

153 The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter semiSWEET.
https://www.preprints.org/manuscript/202004.0512/v1

152 Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors.
https://science.sciencemag.org/content/368/6489/409

151 Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry.
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008392

150 Structural insight into arenavirus replication machinery.
https://www.nature.com/articles/s41586-020-2114-2

149 Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures.
https://www.cell.com/cell/fulltext/S0092-8674(20)30055-6

148 Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex.
https://www.cell.com/cell/fulltext/S0092-8674(20)30054-4

147 Architecture of the mycobacterial type VII secretion system.
https://www.nature.com/articles/s41586-019-1633-1

146 Insight into the Structure of the “Unstructured” Tau Protein.
https://www.cell.com/structure/fulltext/S0969-2126(19)30309-0?utm_medium=homepage

145 Structure and mechanism of the cation–chloride cotransporter NKCC1.
https://www.nature.com/articles/s41586-019-1438-2

144 Drugging an undruggable pocket on KRAS.
https://www.pnas.org/content/116/32/15823

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