405 Hypermutable DNA chronicles the evolution of human colon cancer.
http://www.pnas.org/content/111/18/E1889.abstract
404 Understanding how inhibitors rewire the Met receptor pathway points to a strategy for more effective gastric cancer treatment.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/322/ra38
403 Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.
http://www.pnas.org/content/111/15/5682.abstract
402 T helper 17 cells play a critical pathogenic role in lung cancer.
http://www.pnas.org/content/111/15/5664.abstract
401 Targeted In Vivo Imaging of Microscopic Tumors with Ferritin-based Nanoprobes Across Biological Barriers.
http://onlinelibrary.wiley.com/doi/10.1002/adma.201304544/abstract
400 Oncogenic microRNA-3151 interferes with the p53-mediated apoptosis pathway to produce more severe leukemia.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/321/ra36
399 Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
http://www.nature.com/nature/journal/v508/n7495/full/nature13194.html
398 MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
http://www.nature.com/nature/journal/v508/n7495/full/nature13181.html
397 The delivery of therapeutics using an external trigger is an attractive route for the improvement of targeted disease treatment. Here, the authors have discovered a porphyrin–phospholipid liposome for light-controlled membrane permeabilization and use the system to deliver an anticancer drug in vivo.
http://www.nature.com/ncomms/2014/140403/ncomms4546/full/ncomms4546.html
396 Triple-negative breast cancers (TNBC) show an increased basal level of endoplasmic reticulum stress and activation of the XBP1 branch of the unfolded protein response; furthermore, XBP1 promotes tumour formation of TNBC cell lines by interacting with and regulating HIF1α.
http://www.nature.com/nature/journal/v508/n7494/full/nature13119.html
395 Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells.
http://stke.sciencemag.org/cgi/content/abstract/7/319/ra31
394 Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer.
http://www.pnas.org/content/111/13/4886.abstract
393 MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells.
http://www.nature.com/ncb/journal/v16/n3/abs/ncb2910.html
392 PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual-Modal CT/Photoacoustic Imaging Guided Photothermal Therapy.
http://onlinelibrary.wiley.com/doi/10.1002/adma.201304497/abstract
391 When therapy leads to cancer metastasis, knowing where else to target in the pathway may be the key to successful treatment.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/318/ra30
390 Measuring DNA repair pathway choice determines the sensitivity of cancers to individual classes of treatment.
http://stm.sciencemag.org/content/6/229/229ra42.abstract
389 Systematic screen of chemotherapeutics in Drosophila stem cell tumors.
http://www.pnas.org/content/111/12/4530.abstract
388 CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis.
http://www.cell.com/cell-stem-cell/abstract/S1934-5909(14)00010-1
387 Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00025-4
386 Fas ligand–mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.
http://www.nature.com/nm/journal/v20/n3/full/nm.3442.html
|
