425 A new mechanism by which acute myeloid leukaemia patients become resistant to Ara-C and a newer treatment, ribavirin, is uncovered; these drugs can be glucuronidated and thereby inactivated by members of the UDP glucuronosyltransferase family of enzymes activated through GLI1 signalling.
http://www.nature.com/nature/journal/v511/n7507/full/nature13283.html
424 COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models.
http://stm.sciencemag.org/content/6/242/242ra84.abstract
423 Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
http://www.nature.com/nature/journal/v510/n7505/full/nature13444.html
422 Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.
http://www.nature.com/ncomms/2014/140625/ncomms5255/full/ncomms5255.html
421 Screening individual cancer cells within a brain tumor may help to guide treatment and predict prognosis.
http://www.sciencemag.org/content/344/6190/1396.abstract
420 Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
http://www.nature.com/nature/journal/v510/n7504/full/nature13229.html
419 Copper chelators could help to reduce metastasis from breast tumors.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/329/ra56
418 PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors.
http://www.pnas.org/content/111/23/E2404.abstract
417 Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach.
http://www.nature.com/ncomms/2014/140603/ncomms5006/full/ncomms5006.html
416 Improved Survival with T Cell Clonotype Stability After Anti–CTLA-4 Treatment in Cancer Patients.
http://stm.sciencemag.org/content/6/238/238ra70
415 Targeting Poly(ADP-Ribose) Polymerase and the c-Myb–Regulated DNA Damage Response Pathway in Castration-Resistant Prostate Cancer.
http://stke.sciencemag.org/cgi/content/abstract/7/326/ra47
414 Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice.
http://www.nature.com/ncomms/2014/140521/ncomms4869/full/ncomms4869.html
413 A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma.
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00119-6
412 γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer.
http://www.cell.com/immunity/abstract/S1074-7613(14)00147-2
411 Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00107-7
410 A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways.
http://stke.sciencemag.org/cgi/content/abstract/7/325/ra44
409 An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.
http://www.nature.com/ncomms/2014/140515/ncomms4626/full/ncomms4626.html
408 An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage.
http://www.nature.com/nm/journal/v20/n5/abs/nm.3519.html
407 T cells specific for a mutation expressed by tumor cells show antitumor activity in a patient with an epithelial cancer.
http://www.sciencemag.org/content/344/6184/641.abstract
406 S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells.
http://www.nature.com/ncomms/2014/140508/ncomms4795/full/ncomms4795.html
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