4 Under certain conditions, endothelial cells can transform into mesenchymal cell types, a process known as endothelial-to-mesenchymal transition. Damian Medici et al. now provide evidence that this type of transition contributes to the generation of the ossified lesions of individuals with fibrodysplasia ossificans progressiva.
Medici D et al. (2010). Nature Medicine 16:1400–1406.
http://www.nature.com/nm/journal/v16/n12/abs/nm.2252.html
3 The first viable rat-mouse chimeras demonstrate that rat induced pluripotent stem (iPS) cells can rescue organ deficiency in mice. Rat iPS cells formed a fully functional pancreas when injected into mouse blastocysts lacking the Pdx1 gene required for pancreas formation.
Kobayashi T . et al. (2010) Cell 142:787-799.
http://www.cell.com/abstract/S0092-8674(10)00843-3
2 Induced pluripotent stem cell–derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
Espejel S. et al. (2010). J Clin Invest. 120: 3120-3126.
http://www.jci.org/articles/view/43267
1 Functional cardiomyocytes can be directly reprogrammed from differentiated somatic cells by defined factors. Reprogramming of endogenous or explanted fibroblasts might provide a source of cardiomyocytes for regenerative approaches.
Ieda et al. (2010). Cell 142:375-386.
http://www.cell.com/abstract/S0092-8674(10)00771-3
|
