Proteome

Articles:

14 A knock-in mutation in beclin 1 that increases autophagy in mice extends animal lifespan, improves healthspan, and also rescues early lethality in mice deficient in the anti-ageing protein klotho.
https://www.nature.com/articles/s41586-018-0162-7

13 Xenoprotein engineering via synthetic libraries.
http://www.pnas.org/content/115/23/E5298

12 Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.
https://www.nature.com/articles/s41586-018-0153-8

11 The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species.
http://science.sciencemag.org/content/360/6389/645

10 A system that combines nanoscale synthesis and affinity ranking enables high-throughput screening of reaction conditions and bioactivity for a given protein target, accelerating the process of drug discovery.
https://www.nature.com/articles/s41586-018-0056-8

9 Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics.
https://pubs.acs.org/doi/10.1021/acscentsci.7b00612

8 A bound reaction intermediate sheds light on the mechanism of nitrogenase.
http://science.sciencemag.org/content/359/6383/1484

7 Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
http://science.sciencemag.org/content/359/6383/eaaq0939

6 Light-activated protein interaction with high spatial subcellular confinement.
http://www.pnas.org/content/115/10/E2238

5 Optically functional isoxanthopterin crystals in the mirrored eyes of decapod crustaceans.
http://www.pnas.org/content/115/10/2299

4 The mechanism by which mitochondrial outer membrane proteins are inserted is elucidated.
http://science.sciencemag.org/content/359/6373/eaah6834

3 Phase separation of a yeast prion protein promotes cellular fitness.
http://science.sciencemag.org/content/359/6371/eaao5654

2 A Method for the Acute and Rapid Degradation of Endogenous Proteins.
http://www.cell.com/cell/fulltext/S0092-8674(17)31255-2

1 C-reactive protein promotes bone destruction in human myeloma through the CD32–p38 MAPK–Twist axis.
http://stke.sciencemag.org/content/10/509/eaan6282

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