81 Cai and colleagues show that the function of adult hypothalamic neural stem cells in mice is impaired following NF-κB activation associated with a chronic high-fat diet, resulting in development of obesity and neurodegenerative features. Mechanistically, NF-κB affects both Notch signalling and apoptosis in these cells.
http://www.nature.com/ncb/journal/v14/n10/abs/ncb2562.html
80 Sugar-Sweetened Beverages and Genetic Risk of Obesity.
http://www.nejm.org/doi/full/10.1056/NEJMoa1203039
79 Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.
http://www.pnas.org/content/109/37/14912.abstract
78 The results of a 23-year study of caloric restriction in rhesus macaques are reported; restricted caloric intake did not increase survival, but improved the metabolic profile of monkeys started at older ages and showed a trend towards delaying age-associated disease in monkeys started at a young age.
http://www.nature.com/nature/journal/v489/n7415/full/nature11432.html
77 Hunter-Gatherer Energetics and Human Obesity.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0040503
76 Antibiotics in early life alter the murine colonic microbiome and adiposity.
http://www.nature.com/nature/journal/v488/n7413/full/nature11400.html
75 Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00277-X
74 Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis.
http://www.pnas.org/content/109/32/13100.abstract
73 A Prospective Study of In-utero Exposure to Magnetic Fields and the Risk of Childhood Obesity.
http://www.nature.com/srep/2012/120727/srep00540/full/srep00540.html
72 Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00243-4
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