91 Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.
http://www.nature.com/nchembio/journal/v9/n2/abs/nchembio.1136.html
90 Estrogen is beneficial for obesity and type 2 diabetes, though its use is limited by important side effects. In a new study, Matthias Tschöp and colleagues avoid this issue by chemically linking estrogen to the hormone GLP-1 to selectively target metabolically relevant tissue and show that the conjugated compound corrects obesity, hyperglycemia and dyslipidemia in mice. This approach could be used for other hormone pairs to treat other diseases.
http://www.nature.com/nm/journal/v18/n12/abs/nm.3009.html
89 A molecular mechanism in the brain and individual tissues allows mammals to adapt to a 24-hour clock. Garret FitzGerald and colleagues now show that genetic deletion of one member of this pathway specifically in the fat of mice results in acutely altered lipid profiles that, in turn, result in increased feeding and obesity. This could explain why human night-shift workers are at an increased risk for obesity and metabolic disease.
http://www.nature.com/nm/journal/v18/n12/abs/nm.2979.html
88 Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.
http://www.pnas.org/content/109/50/20555.abstract
87 An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
http://www.nature.com/nature/journal/v492/n7428/full/nature11654.html
86 The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466591/
85 Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex.
http://stm.sciencemag.org/content/4/162/162ra153.abstract
84 Warming-induced reductions in body size are greater in aquatic than terrestrial species.
http://www.pnas.org/content/109/47/19310
83 A Fructose Receptor Functions as a Nutrient Sensor in the Drosophila Brain.
http://www.cell.com/abstract/S0092-8674(12)01246-9
82 Mice lacking an orphan G protein–coupled receptor show reduced inflammatory signaling and obesity.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/251/ra85
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