454 The authors present a human pluripotent stem cell-derived three-dimensional organoid culture system that is able to recapitulate several aspects of human brain development in addition to modelling the brain disorder microcephaly, which has been difficult to achieve using mouse models.
http://www.nature.com/nature/journal/v501/n7467/full/nature12517.html
453 Human LilrB2 Is a β-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer’s Model.
http://www.sciencemag.org/content/341/6152/1399
452 Octopamine-mediated circuit mechanism underlying controlled appetite for palatable food in Drosophila.
http://www.pnas.org/content/110/38/15431.abstract
451 Nonhuman primate model of schizophrenia using a noninvasive EEG method.
http://www.pnas.org/content/110/38/15425.abstract
450 Activation of the central nervous system induced by micro-magnetic stimulation.
http://www.nature.com/ncomms/2013/130913/ncomms3463/full/ncomms3463.html
449 Distinct Representations of Cognitive and Motivational Signals in Midbrain Dopamine Neurons.
http://www.cell.com/neuron/abstract/S0896-6273(13)00567-9
448 Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimers Disease.
http://www.cell.com/neuron/abstract/S0896-6273(13)00562-X
447 Molecular Structure of β-Amyloid Fibrils in Alzheimers Disease Brain Tissue.
http://www.cell.com/abstract/S0092-8674(13)01029-5
446 Exome sequencing has found an excess of de novo mutations in the ~4,000 most intolerant genes in patients with two classical epileptic encephalopathies (infantile spasms and Lennox–Gastaut syndrome); among them are multiple de novo mutations in GABRB3 and ALG13.
http://www.nature.com/nature/journal/v501/n7466/full/nature12439.html
445 Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.
http://www.nature.com/nature/journal/v501/n7466/full/nature12518.html
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