27 Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. Gregorio J, et al. (2010). JEM 207: 2921-2930.
http://jem.rupress.org/content/207/13/2921.abstract
26 Single dose of anti–CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance.
Pedicord VA et al. (2011)PNAS 108: 266-271.
http://www.pnas.org/content/108/1/266.abstract
25 MicroRNAs Prevent the Generation of Autoreactive Antibodies.
Belver L et al, (2010). Immunity 33: 713-722.
http://www.cell.com/immunity/abstract/S1074-7613(10)00416-4
24 CD14 is a coreceptor of Toll-like receptors 7 and 9.
Baumann CL et al, (2010). J. Exp Med. 2689-2701.
http://jem.rupress.org/content/207/12/2689.abstract
23 Pyroptosis is a form of proinflammatory cell suicide whose physiological importance is unclear. Aderem and colleagues show that pyroptosis can be integral to protection against bacterial infection.
Miao EA et al. (2010) . Nature Immunology 11: 1136-1142.
http://www.nature.com/ni/journal/v11/n12/abs/ni.1960.html
22 MHC class I alleles are the major genetic determinants associated with people able to control HIV infection without therapy.
The International HIV Controllers Study. (2010) Science 330: 1551-1557.
http://www.sciencemag.org/content/330/6010/1551.abstract
21 A protein (MCl-1) that inhibits apoptosis is essential for the survival of immune memory cells.
Vikstrom I, et al. (2010) Science 330: 1095-1099.
http://www.sciencemag.org/content/330/6007/1095.abstract
20 The Ets-1 transcription factor controls the development and function of natural regulatory T cells.
Mouly E. et al. (2010). J. Exp. Med. 207: 2113-2125.
http://jem.rupress.org/content/207/10/2113.abstract
19 CD11c depletion severely disrupts Th2 induction and development in vivo
Phythian-Adams AT. et al. (2010). J. Exp. Med. 207: 2089-2096
http://jem.rupress.org/content/207/10/2089.abstract
18 Immune cells that recognize 'self' tissues need to be eliminated or controlled in order to prevent autoimmune diseases. Here, a T-cell population is delineated that is necessary to maintain self tolerance in mice. Genetic disruption of the inhibitory interaction between these CD8+ T cells and their target Qa-1+ follicular T-helper cells results in a lethal systemic-lupus-erythematosus-like autoimmune disease.
Kim HJ. et al. (2010). Nature 467: 328-332.
http://www.nature.com/nature/journal/v467/n7313/abs/nature09370.html
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