425 Consistent scaling of inbreeding depression in space and time in a house sparrow metapopulation.
https://www.pnas.org/content/117/25/14584
424 Sex chromosomes must exchange genetic information at a short region during meiotic cell division. Molecular factors have now been found that alter sex-chromosome structure and enhance this exchange process.
https://www.nature.com/articles/d41586-020-01483-6
423 Differences in color between male and female canaries and finches map to simple molecular mechanisms driven by genes with large effects.
https://science.sciencemag.org/content/368/6496/1270
422 Insights into human genetic variation and population history from 929 diverse genomes.
https://science.sciencemag.org/content/367/6484/eaay5012
421 A highly soluble Sleeping Beauty transposase improves control of gene insertion.
https://www.nature.com/articles/s41587-019-0291-z
420 Using whole-genome sequencing data from 1,739 individuals, the GenomeAsia 100K Project catalogues genetic variation, population structure and disease associations to facilitate genetic studies in Asian populations and increase representation in genetics studies worldwide.
https://www.nature.com/articles/s41586-019-1793-z
419 A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.
https://www.cell.com/cell/fulltext/S0092-8674(19)31176-6
418 Correcting a protein network that regulates proteostasis reverses deficits in a mouse model of Down syndrome.
https://science.sciencemag.org/content/366/6467/843
417 The degree to which a genome can tolerate mutations is inversely correlated with the fitness of a yeast strain.
https://science.sciencemag.org/content/366/6464/490
416 Search-and-replace genome editing without double-strand breaks or donor DNA.
https://www.nature.com/articles/s41586-019-1711-4
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