45 Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.
http://www.jci.org/articles/view/59227
44 CBX7 is a tumor suppressor in mice and humans.
http://www.jci.org/articles/view/58620
43 An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.
http://www.jci.org/articles/view/59309
42 Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.
http://jem.rupress.org/content/209/2/275.abstract
41 Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA.
http://www.pnas.org/content/109/8/3024.abstract
40 Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia.
http://www.pnas.org/content/109/8/2784.abstract
39 Defining the cellular precursors to human breast cancer.
http://www.pnas.org/content/109/8/2772.abstract
38 Leukocyte composition of human breast cancer.
http://www.pnas.org/content/109/8/2796.abstract
37 Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells.
http://www.pnas.org/content/109/8/2778.abstract
36 Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses.
http://stm.sciencemag.org/content/4/120/120ra16.abstract
35 Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors.
http://www.pnas.org/content/109/6/2066.abstract
34 Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.
http://www.pnas.org/content/109/6/E353.abstract
33 Recurrent histone mutations are linked to paediatric glioblastoma multiforme, an aggressive type of brain tumour.
http://www.nature.com/nature/journal/v482/n7384/full/nature10833.html
32 A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer.
http://www.cell.com/cell-stem-cell/abstract/S1934-5909(12)00002-1
31 Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas.
http://www.nature.com/neuro/journal/v15/n2/abs/nn.3019.html
30 Key contribution of CPEB4-mediated translational control to cancer progression.
http://www.nature.com/nm/journal/v18/n1/abs/nm.2540.html
29 The structures of CYP17A1 with steroid inhibitors abiraterone or TOK-001 provide a better understanding of the enzyme’s catalytic capabilities and inhibition, and hence assist in understanding steroidogenic diseases and designing drugs to improve the treatment of prostate and other steroid-responsive cancers.
http://www.nature.com/nature/journal/v482/n7383/full/nature10743.html
28 Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.
http://www.pnas.org/content/109/5/1643.abstract
27 Brush border Myosin Ia has tumor suppressor activity in the intestine.
http://www.pnas.org/content/109/5/1530.abstract
26 Shifting from Population-wide to Personalized Cancer Prognosis with Microarrays.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029534
|
