957 Actively personalized vaccination trial for newly diagnosed glioblastoma.
https://www.nature.com/articles/s41586-018-0810-y
956 Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.
https://www.nature.com/articles/s41586-018-0792-9
955 De novo design of potent and selective mimics of IL-2 and IL-15.
https://www.nature.com/articles/s41586-018-0830-7
954 Deletion of the A-to-I double-stranded RNA-editing enzyme ADAR1 sensitizes tumour cells to immunotherapy.
https://www.nature.com/articles/s41586-018-0768-9
953 Organoid Modeling of the Tumor Immune Microenvironment.
https://www.cell.com/cell/fulltext/S0092-8674(18)31513-7
952 Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture.
https://www.pnas.org/content/115/50/E11671
951 Altered ubiquitination of RAS GTPases is implicated in cancer drug resistance.
http://science.sciencemag.org/content/362/6419/1171
950 Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.
http://science.sciencemag.org/content/362/6418/1055
949 Single-cell multiomics sequencing and analyses of human colorectal cancer.
http://science.sciencemag.org/content/362/6418/1060
948 Mannose impairs tumour growth and enhances chemotherapy.
https://www.nature.com/articles/s41586-018-0729-3
947 Cancer-associated mutations are surprisingly common in normal esophageal epithelium from human donors.
http://science.sciencemag.org/content/362/6417/911
946 Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.
http://www.pnas.org/content/115/47/E11091
945 The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
https://www.nature.com/articles/s41586-018-0701-2
944 An immunoprecipitation-based protocol is developed to analyse DNA methylation in small quantities of circulating cell-free DNA, and can detect and classify cancers in plasma samples from several tumour types.
https://www.nature.com/articles/s41586-018-0703-0
943 Autophagy maintains tumour growth through circulating arginine.
https://www.nature.com/articles/s41586-018-0697-7
942 Enhanced detection of circulating tumor DNA by fragment size analysis.
http://stm.sciencemag.org/content/10/466/eaat4921
941 Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
https://www.nature.com/articles/s41586-018-0629-6
940 Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer.
https://pubs.acs.org/doi/10.1021/acsnano.8b02481
939 Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers.
https://pubs.acs.org/doi/10.1021/acsnano.8b00967
938 Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles.
https://pubs.acs.org/doi/10.1021/acsnano.8b04146
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