1097 An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors.
https://science.sciencemag.org/content/early/2019/12/30/science.aay5967
1096 Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer.
https://stm.sciencemag.org/content/12/524/eaax7533
1095 An artificial intelligence (AI) system performs as well as or better than radiologists at detecting breast cancer from mammograms, and using a combination of AI and human inputs could help to improve screening efficiency.
https://www.nature.com/articles/s41586-019-1799-6
1094 IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.
https://rupress.org/jcb/article-abstract/219/2/e201903017/133547/IPO11-mediates-catenin-nuclear-import-in-a-subset?redirectedFrom=fulltext
1093 Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus.
https://www.pnas.org/content/116/52/26909
1092 Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.
https://www.pnas.org/content/116/52/26580
1091 Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body.
https://www.cell.com/cell/fulltext/S0092-8674(19)31269-3
1090 The GLASS Consortium studies the evolutionary trajectories of 222 patients with a diffuse glioma to aid in our understanding of tumour progression and treatment failure.
https://www.nature.com/articles/s41586-019-1775-1
1089 Imaging and sequencing approaches are combined to show that extrachromosomal DNA (ecDNA) in cancer is circular and has unique chromatin structure that amplifies oncogene output.
https://www.nature.com/articles/s41586-019-1763-5
1088 Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.
https://science.sciencemag.org/content/366/6468/1029
1087 Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation.
https://www.nature.com/articles/s43018-019-0004-z
1086 Immunity to commensal papillomaviruses protects against skin cancer.
https://www.nature.com/articles/s41586-019-1719-9
1085 Mouse models of triple-negative breast cancer provide insights into how T follicular helper cell activation of B cells facilitates the effects of immune checkpoint inhibitors.
https://www.cell.com/cell/fulltext/S0092-8674(19)31178-X
1084 The Role of Non-coding RNAs in Oncology. (Review).
https://www.cell.com/cell/fulltext/S0092-8674(19)31167-5#%20
1083 An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma.
https://www.pnas.org/content/116/46/23264
1082 Pan-cancer whole-genome analyses of metastatic solid tumours.
https://www.nature.com/articles/s41586-019-1689-y
1081 The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
https://www.nature.com/articles/s41586-019-1694-1
1080 Small cell lung cancer tumors are sensitive to DHODH inhibition, highlighting a potential treatment strategy for this disease.
https://stm.sciencemag.org/content/11/517/eaaw7852
1079 Some breast cancers harbor not one—but two—PIK3CA mutations, and this enhances their response to certain drugs.
https://science.sciencemag.org/content/366/6466/714
1078 The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients.
https://cancerdiscovery.aacrjournals.org/content/early/2019/10/22/2159-8290.CD-19-1167
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