1117 A single-cell, spatially resolved analysis of breast cancer demonstrates the heterogeneity of tumour and stroma tissue and provides a more-detailed method of patient classification than the current histology-based system.
https://www.nature.com/articles/s41586-019-1876-x
1116 Epigenetic therapy inhibits metastases by disrupting premetastatic niches.
https://www.nature.com/articles/s41586-020-2054-x
1115 Proteogenomic analyses of prospectively collected endometrial carcinomas provide insights into the role of underlying molecular pathways and the immune landscape that drive disease.
https://www.cell.com/cell/fulltext/S0092-8674(20)30107-0
1114 AQP5 enriches for stem cells and cancer origins in the distal stomach.
https://www.nature.com/articles/s41586-020-1973-x
1113 Loss of p53 drives neuron reprogramming in head and neck cancer.
https://www.nature.com/articles/s41586-020-1996-3
1112 Combining microenvironment normalization strategies to improve cancer immunotherapy.
https://www.pnas.org/content/117/7/3728
1111 Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction.
https://www.pnas.org/content/117/7/3748
1110 Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies.
https://stm.sciencemag.org/content/12/530/eaax0876
1109 Tobacco smoking and somatic mutations in human bronchial epithelium.
https://www.nature.com/articles/s41586-020-1961-1
1108 Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
https://www.nature.com/articles/s41586-020-1930-8
1107 Pan-cancer analysis of whole genomes.
https://www.nature.com/articles/s41586-020-1969-6
1106 An epigenetic therapy can eliminate preleukemia cells and delay leukemia development in a mouse model.
https://science.sciencemag.org/content/367/6477/586
1105 In a mouse model of glioblastoma, treatment with VEGF-C increases lymphatic drainage in the central nervous system and improves the immune response, suggesting that modulating meningeal lymphatics could enhance checkpoint inhibitor therapy.
https://www.nature.com/articles/s41586-019-1912-x
1104 An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors.
https://science.sciencemag.org/content/367/6476/446
1103 High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.
https://www.pnas.org/content/117/3/1666
1102 Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth.
https://advances.sciencemag.org/content/6/3/eaay2174
1101 Oncolytic vaccinia virus encoding IL-7 and IL-12 facilitates immune checkpoint blockade in treatment-resistant solid tumors.
https://stm.sciencemag.org/content/12/526/eaax7992
1100 Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.
https://stm.sciencemag.org/content/12/526/eaax9340
1099 Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer.
https://www.pnas.org/content/early/2019/12/26/1904022116
1098 HBO1 is required for the maintenance of leukaemia stem cells.
https://www.nature.com/articles/s41586-019-1835-6
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