2 To identify genes affecting traits of interest in E. coli, Warner et al. describe a method to rapidly create and assay rationally mutated versions of every gene. The approach is applied to several traits, including tolerance to cellulosic hydrolysate, a biofuel precursor.
Warner JR. (2010). Nature Biotechnology 28: 856-862.
http://www.nature.com/nbt/journal/v28/n8/abs/nbt.1653.html
1 Harald Ott and his colleagues develop a new way to bioengineer a functioning lung. Through a process of decellularization, seeding with endothelial and epithelial cells, and maturation in an innovative bioreactor system, followed by transplantation into rats of the regenerated lungs in orthotopic position, the group was able to demonstrate adequate ventilation, blood flow and gas exchange in vivo for short periods of time.
Ott HC. et al. (2010). Nature Medicine 16: 927-933.
http://www.nature.com/nm/journal/v16/n8/abs/nm.2193.html
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