23 Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.
http://www.nature.com/ng/journal/v45/n11/abs/ng.2758.html
22 Skin cells from a patient with retinitis pigmentosa have been used to generate induced pluripotent stem cells, which could potentially form the basis of new treatments for this disease.
http://elife.elifesciences.org/content/2/e00824
21 Melatonin stimulates a heteromeric G protein–coupled receptor to modulate the eye’s response to light flashes at night.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/296/ra89
20 Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina.
http://www.pnas.org/content/110/41/16586.abstract
19 Angiopoietin-1 supplementation stimulates guided angiogenesis and promotes the formation of a healthy vascular network in a mouse model of ischemic retinopathy.
http://stm.sciencemag.org/content/5/203/203ra127.abstract
18 Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina.
http://www.nature.com/nbt/journal/v31/n8/full/nbt.2643.html
17 Optical imaging of the chorioretinal vasculature in the living human eye.
http://www.pnas.org/content/110/35/14354.abstract
16 In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous.
http://stm.sciencemag.org/content/5/189/189ra76
15 Impaired Cholesterol Efflux in Senescent Macrophages Promotes Age-Related Macular Degeneration.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00113-7
14 Primary sensory areas of newborn mammals typically display input-dependent plasticity. Thomson and colleagues use a sensory prosthetic device in rats to show that adult rats can discriminate different infrared light signals, when the signals are routed to somatosensory cortex by electrical microstimulation.
http://www.nature.com/ncomms/journal/v4/n2/full/ncomms2497.html
13 An embedded system for aiding navigation of visually impaired persons.
http://www.currentscience.ac.in/Volumes/104/03/0302.pdf
12 Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
http://www.pnas.org/content/110/6/E507.abstract
11 JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration.
http://www.pnas.org/content/110/6/2377.abstract
10 Reprogramming of adult rod photoreceptors prevents retinal degeneration.
http://www.pnas.org/content/110/5/1732.abstract
9 Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.
http://www.pnas.org/content/110/3/1101.abstract
8 Repair of the degenerate retina by photoreceptor transplantation.
http://www.pnas.org/content/110/1/354.abstract
7 Goldman and colleagues report that the transcriptional repressor Insm1a is essential for retinal regeneration following injury in fish. Insm1a suppresses the expression of Ascl1a to promote Müller glial cells’ dedifferentiation at early stages of regeneration, and defines the regeneration zone by negatively regulating the expression of the heparin-binding EGF. It also halts the proliferation of retinal progenitors in the late stages of the process.
http://www.nature.com/ncb/journal/v14/n10/abs/ncb2586.html
6 Retinal prosthetic strategy with the capacity to restore normal vision.
http://www.pnas.org/content/109/37/15012.abstract
5 Restoration of vision after transplantation of photoreceptors.
http://www.nature.com/nature/journal/v485/n7396/full/nature10997.html
4 Photovoltaic retinal prosthesis with high pixel density.
http://www.nature.com/nphoton/journal/v6/n6/abs/nphoton.2012.104.html
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