61 Chemical and genetic validation of thiamine utilization as an antimalarial drug target.
http://www.nature.com/ncomms/2013/130627/ncomms3060/full/ncomms3060.html
60 Silver enhances the activity of a wide range of antibiotics and broadens the spectrum of vancomycin, rendering it effective against Gram-negative bacteria.
http://stm.sciencemag.org/content/5/190/190ra81.abstract
59 Clomiphene and toremifene inhibit Ebola virus infection.
http://stm.sciencemag.org/content/5/190/190ra79.abstract
58 Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity.
http://www.pnas.org/content/110/25/10282.abstract
57 Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance.
http://www.pnas.org/content/110/24/E2239.abstract
56 Designing responsive microgels for drug delivery applications.
http://onlinelibrary.wiley.com/doi/10.1002/pola.26707/abstract
55 Combined effect of a peptide–morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic.
http://www.pnas.org/content/110/21/8686.abstract
54 Saccharomyces cerevisiae is engineered to produce high concentrations of artemisinic acid, a precursor of the artemisinin used in combination therapies for malaria treatment; an efficient and practical chemical process to convert artemisinic acid to artemisinin is also developed.
http://www.nature.com/nature/journal/v496/n7446/full/nature12051.html
53 Enantioselective Synthesis of Pactamycin, a Complex Antitumor Antibiotic.
http://www.sciencemag.org/content/340/6129/180.abstract
52 A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase.
http://www.cell.com/chemistry-biology/abstract/S1074-5521(13)00035-5
51 Piperazine and Piperidine Triazole Ureas as Ultrapotent and Highly Selective Inhibitors of Monoacylglycerol Lipase.
http://www.cell.com/chemistry-biology/abstract/S1074-5521(13)00038-0
50 Identification of a Broad-Spectrum Inhibitor of Viral RNA Synthesis: Validation of a Prototype Virus-Based Approach.
http://www.cell.com/chemistry-biology/abstract/S1074-5521(13)00081-1
49 Quinolone-3-Diarylethers: A New Class of Antimalarial Drug.
http://stm.sciencemag.org/content/5/177/177ra37
48 Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
http://www.nature.com/ncomms/journal/v4/n2/full/ncomms2506.html
47 Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication.
http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2012.264.html
46 ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
http://www.nature.com/nature/journal/v494/n7435/full/nature11774.html
45 Antibacterial drug leads targeting isoprenoid biosynthesis.
http://www.pnas.org/content/110/1/123.abstract
44 Automated design of ligands to polypharmacological profiles.
http://www.nature.com/nature/journal/v492/n7428/full/nature11691.html
43 Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex.
http://stm.sciencemag.org/content/4/162/162ra153.abstract
42 Lithographically Encoded Polymer Microtaggant Using High-Capacity and Error-Correctable QR Code for Anti-Counterfeiting of Drugs.
http://onlinelibrary.wiley.com/doi/10.1002/adma.201201486/abstract
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