88 Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.
http://www.pnas.org/content/109/50/20555.abstract
87 An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
http://www.nature.com/nature/journal/v492/n7428/full/nature11654.html
86 The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466591/
85 Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex.
http://stm.sciencemag.org/content/4/162/162ra153.abstract
84 Warming-induced reductions in body size are greater in aquatic than terrestrial species.
http://www.pnas.org/content/109/47/19310
83 A Fructose Receptor Functions as a Nutrient Sensor in the Drosophila Brain.
http://www.cell.com/abstract/S0092-8674(12)01246-9
82 Mice lacking an orphan G protein–coupled receptor show reduced inflammatory signaling and obesity.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/251/ra85
81 Cai and colleagues show that the function of adult hypothalamic neural stem cells in mice is impaired following NF-κB activation associated with a chronic high-fat diet, resulting in development of obesity and neurodegenerative features. Mechanistically, NF-κB affects both Notch signalling and apoptosis in these cells.
http://www.nature.com/ncb/journal/v14/n10/abs/ncb2562.html
80 Sugar-Sweetened Beverages and Genetic Risk of Obesity.
http://www.nejm.org/doi/full/10.1056/NEJMoa1203039
79 Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.
http://www.pnas.org/content/109/37/14912.abstract
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