96 Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus.
http://www.nature.com/nm/journal/v19/n3/abs/nm.3084.html
95 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet.
http://www.nejm.org/doi/full/10.1056/NEJMoa1200303?query=featured_home
94 Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055542
93 Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity.
http://www.nature.com/srep/2013/130213/srep01254/full/srep01254.html
92 Bacterial Nitric Oxide Extends the Lifespan of C. elegans.
http://www.cell.com/abstract/S0092-8674(13)00014-7
91 Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.
http://www.nature.com/nchembio/journal/v9/n2/abs/nchembio.1136.html
90 Estrogen is beneficial for obesity and type 2 diabetes, though its use is limited by important side effects. In a new study, Matthias Tschöp and colleagues avoid this issue by chemically linking estrogen to the hormone GLP-1 to selectively target metabolically relevant tissue and show that the conjugated compound corrects obesity, hyperglycemia and dyslipidemia in mice. This approach could be used for other hormone pairs to treat other diseases.
http://www.nature.com/nm/journal/v18/n12/abs/nm.3009.html
89 A molecular mechanism in the brain and individual tissues allows mammals to adapt to a 24-hour clock. Garret FitzGerald and colleagues now show that genetic deletion of one member of this pathway specifically in the fat of mice results in acutely altered lipid profiles that, in turn, result in increased feeding and obesity. This could explain why human night-shift workers are at an increased risk for obesity and metabolic disease.
http://www.nature.com/nm/journal/v18/n12/abs/nm.2979.html
88 Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.
http://www.pnas.org/content/109/50/20555.abstract
87 An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
http://www.nature.com/nature/journal/v492/n7428/full/nature11654.html
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