161 Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00456-7
160 Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00457-9
159 Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits.
http://www.cell.com/abstract/S0092-8674(13)01550-X
158 Clathrin adaptor Numb recognizes a peptide motif within the cholesterol transporter NPC1L1 upon cholesterol binding and thus facilitates dietary cholesterol uptake into the gut. Inhibition of this Numb-NPC1L1 interaction in mice reduces serum cholesterol levels and thus may be a therapeutic target to treat hypercholesterolemia in the clinic.
http://www.nature.com/nm/journal/v20/n1/abs/nm.3417.html
157 Reprogramming of the Circadian Clock by Nutritional Challenge.
http://www.cell.com/abstract/S0092-8674(13)01485-2
156 Development of small-molecule inhibitors targeting adipose triglyceride lipase.
http://www.nature.com/nchembio/journal/v9/n12/abs/nchembio.1359.html
155 An orally active small molecule, AdipRon, that binds to and activates both adiponectin receptors (AdipoR1 and AdipoR2) is identified; it ameliorates diabetes in mice on a high-fat diet and in genetically obese db/db mice, and if this can be extrapolated to humans, orally active agonists such as AdipoRon are a promising new approach to treat obesity-related diseases such as type 2 diabetes.
http://www.nature.com/nature/journal/v503/n7477/full/nature12656.html
154 The activity of a specific metabolite of cholesterol may help explain why obesity is a risk factor for breast cancer.
http://www.sciencemag.org/content/342/6162/1094.abstract
153 Association of Nut Consumption with Total and Cause-Specific Mortality.
http://www.nejm.org/doi/full/10.1056/NEJMoa1307352
152 Long-term treatment of obese, insulin-resistant nonhuman primates with a seed-targeting antimiR oligonucleotide against the microRNA-33 family derepresses hepatic expression of miR-33 targets, increases circulating HDL cholesterol, and has a clean safety profile.
http://stm.sciencemag.org/content/5/212/212ra162.abstract
|
