181 Extended lifespan and reduced adiposity in mice lacking the FAT10 gene.
http://www.pnas.org/content/111/14/5313.abstract
180 Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.
http://www.pnas.org/content/111/14/5242.abstract
179 David Altshuler and colleagues report genotyping or sequencing of ~150,000 individuals from several population-based cohorts, identifying 12 rare protein-truncating variants in SLC30A8, encoding a pancreatic islet zinc transporter. Carriers of these rare protein-truncating variants in SLC30A8 show reduced risk of type 2 diabetes and reduced glucose levels.
http://www.nature.com/ng/journal/v46/n4/abs/ng.2915.html
178 Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans.
http://www.nature.com/nature/journal/v508/n7494/full/nature13012.html
177 Therapeutic vaccine against DPP4 improves glucose metabolism in mice.
http://www.pnas.org/content/111/13/E1256.abstract
176 Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys.
http://www.nature.com/ncomms/2014/140401/ncomms4557/full/ncomms4557.html
175 Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00057-6
174 The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00065-5
173 Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00062-X
172 Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity.
http://www.nature.com/ncomms/2014/140312/ncomms4427/full/ncomms4427.html
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