1375 Loss of ataxin-1 leads to increases in BACE1 levels as well as amyloidogenic cleavage of APP, leading to Aβ deposition and gliosis in mouse models of Alzheimer’s disease.
https://www.cell.com/cell/fulltext/S0092-8674(19)30843-8
1374 A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
https://www.nature.com/articles/s41587-019-0205-0
1373 A nanoimmunotherapy reduces inflammation in mouse, rabbit, and pig models of atherosclerosis.
https://stm.sciencemag.org/content/11/506/eaaw7736
1372 Adeno-associated viral vector serotype 9–based gene therapy for Niemann-Pick disease type A.
https://stm.sciencemag.org/content/11/506/eaat3738
1371 A study of the functional microbiome in a mouse model of ALS shows that several gut bacteria may modulate the severity of the disease.
https://www.nature.com/articles/s41586-019-1443-5
1370 In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.
https://www.pnas.org/content/116/23/11490
1369 Specialized cutaneous Schwann cells initiate pain sensation.
https://science.sciencemag.org/content/365/6454/695
1368 Improved speed, brightness, and photostability of voltage sensors allows simultaneous imaging of many neurons.
https://science.sciencemag.org/content/365/6454/699
1367 The mechanism of β-amyloid–dependent neuronal hyperactivity in mouse models of Alzheimer’s disease is elucidated.
https://science.sciencemag.org/content/365/6453/559
1366 Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice.
https://stm.sciencemag.org/content/11/503/eaau0164
|
