294 A component of cerebrospinal fluid in excessively sleepy people activates an inhibitory signaling pathway and mimics the actions of sedative-hypnotics.
http://stm.sciencemag.org/content/4/161/161ra151.abstract
293 Light-activated gene therapy acutely suppresses seizures, and gene therapy with a potassium channel prevents epileptogenesis and treats established epilepsy in a rodent model.
http://stm.sciencemag.org/content/4/161/161ra152.abstract
292 Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice.
http://www.sciencemag.org/content/338/6109/949.abstract
291 MicroRNA-223 is neuroprotective by targeting glutamate receptors.
http://www.pnas.org/content/109/46/18962.abstract
290 Cai and colleagues show that the function of adult hypothalamic neural stem cells in mice is impaired following NF-κB activation associated with a chronic high-fat diet, resulting in development of obesity and neurodegenerative features. Mechanistically, NF-κB affects both Notch signalling and apoptosis in these cells.
http://www.nature.com/ncb/journal/v14/n10/abs/ncb2562.html
289 CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease.
http://www.nature.com/ncomms/journal/v3/n10/full/ncomms2149.html
288 Development of white matter and reading skills.
http://www.pnas.org/content/109/44/E3045.abstract
287 From simple innate biases to complex visual concepts.
http://www.pnas.org/content/109/44/18215
286 Prolonged nerve blockade delays the onset of neuropathic pain.
http://www.pnas.org/content/109/43/17555.abstract
285 A new class of peptides, mambalgins, is isolated from the African snake the black mamba, which can abolish pain through inhibition of particular subtypes of acid-sensing ion channels expressed either in central or peripheral neurons.
http://www.nature.com/nature/journal/v490/n7421/full/nature11494.html
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