290 Cai and colleagues show that the function of adult hypothalamic neural stem cells in mice is impaired following NF-κB activation associated with a chronic high-fat diet, resulting in development of obesity and neurodegenerative features. Mechanistically, NF-κB affects both Notch signalling and apoptosis in these cells.
http://www.nature.com/ncb/journal/v14/n10/abs/ncb2562.html
289 CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease.
http://www.nature.com/ncomms/journal/v3/n10/full/ncomms2149.html
288 Development of white matter and reading skills.
http://www.pnas.org/content/109/44/E3045.abstract
287 From simple innate biases to complex visual concepts.
http://www.pnas.org/content/109/44/18215
286 Prolonged nerve blockade delays the onset of neuropathic pain.
http://www.pnas.org/content/109/43/17555.abstract
285 A new class of peptides, mambalgins, is isolated from the African snake the black mamba, which can abolish pain through inhibition of particular subtypes of acid-sensing ion channels expressed either in central or peripheral neurons.
http://www.nature.com/nature/journal/v490/n7421/full/nature11494.html
284 Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau.
http://www.nature.com/srep/2012/121003/srep00700/full/srep00700.html
283 Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy.
http://www.sciencemag.org/content/338/6105/394.abstract
282 Epidermal growth factor receptor is a preferred target for treating Amyloid-β–induced memory loss.
http://www.pnas.org/content/109/41/16743
281 Small heat-shock proteins protect from heat-stroke-associated neurodegeneration.
http://www.nature.com/nature/journal/v490/n7419/full/nature11417.html
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