324 Chronic inflammation is a feature of the ageing brain and some neurodegenerative diseases; the authors show that astrocytes normally suppress neuroinflammation through activation of their DRD2 receptor by CRYAB, potentially opening new avenues for treatments.
http://www.nature.com/nature/journal/v494/n7435/full/nature11748.html
323 Extensive changes in DNA methylation are associated with expression of mutant huntingtin.
http://www.pnas.org/content/110/6/2354.abstract
322 Professional athletes have extraordinary skills for rapidly learning complex and neutral dynamic visual scenes.
http://www.nature.com/srep/2013/130129/srep01154/full/srep01154.html
321 Alzheimer’s-prone mice deficient in NLRP3 or caspase-1 fail to develop learning deficits and show reduced neuropathology.
http://www.nature.com/nature/journal/v493/n7434/full/nature11729.html
320 Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo.
http://www.nature.com/nature/journal/v493/n7434/full/nature11810.html
319 Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology.
http://www.pnas.org/content/110/5/1941.abstract
318 Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits.
http://www.cell.com/abstract/S0092-8674(12)01433-X
317 Artificial Selection on Relative Brain Size in the Guppy Reveals Costs and Benefits of Evolving a Larger Brain.
http://www.cell.com/current-biology/abstract/S0960-9822(12)01438-8
316 Identification of an essential endogenous regulator of blood–brain barrier integrity, and its pathological and therapeutic implications.
http://www.pnas.org/content/110/3/832.abstract
315 Mice overexpressing eIF4E show autism-related behaviours and altered synaptic activity in the hippocampus, prefrontal cortex and striatum, and these phenotypes can be rescued with the cap-dependent translation inhibitor 4EGI-1.
http://www.nature.com/nature/journal/v493/n7432/full/nature11782.html
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