494 A cholinergic trigger drives learning-induced plasticity at hippocampal synapses.
http://www.nature.com/ncomms/2013/131112/ncomms3760/full/ncomms3760.html
493 Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress.
http://www.nature.com/ncomms/2013/131112/ncomms3753/full/ncomms3753.html
492 Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid .
http://www.nature.com/neuro/journal/v16/n11/abs/nn.3540.html
491 There is currently no effective treatment for infantile neuronal ceroid lipofuscinosis, a neurodegenerative lysosomal storage disease that occurs in childhood. Here the authors show that a small molecule thioesterase-mimetic can alleviate neuropathology and extend lifespan in an animal model of the disease.
http://www.nature.com/neuro/journal/v16/n11/abs/nn.3526.html
490 Dysfunction of the potassium-chloride cotransporter KCC2 has been linked to many neurological diseases, including pain, anxiety and epilepsy. Now, Yves De Koninck and his colleagues report that they have developed a novel small-molecule compound that is orally bioavailable and can activate KCC2 and reduce chronic pain in rats.
http://www.nature.com/nm/journal/v19/n11/abs/nm.3356.html
489 Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by loss of the translational repressor protein FMRP. Now, Joel D. Richter and his colleagues report that knocking down the expression of the translational activator protein CPEB can restore normal levels of translation and rescue behavioral deficits in a mouse model of FXS.
http://www.nature.com/nm/journal/v19/n11/abs/nm.3353.html
488 Balanced feedback loops in a receptor tyrosine kinase network control glial and neuronal differentiation in the fly eye.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/300/ra96
487 Mouse and human studies reveal that incorrect gene dosage of SHANK3 (a gene linked to some human neuropsychiatric disorders, including autism spectrum disorder) is associated with behavioural abnormalities including mania, possibly because of actin regulation problems in excitatory/inhibitory synapses.
http://www.nature.com/nature/journal/v503/n7474/full/nature12630.html
486 A neural circuit from the parabrachial nucleus to the central nucleus of the amygdala mediates appetite suppression.
http://www.nature.com/nature/journal/v503/n7474/full/nature12596.html
485 The transcription factor NPAS4 enables neurons to distinguish synaptic inputs received at their soma or dendrites; sensory stimulation increases NPAS4 which promotes inhibitory synapses on the soma and destabilizes inhibitory synapses on the dendrites.
http://www.nature.com/nature/journal/v503/n7474/full/nature12743.html
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