490 Dysfunction of the potassium-chloride cotransporter KCC2 has been linked to many neurological diseases, including pain, anxiety and epilepsy. Now, Yves De Koninck and his colleagues report that they have developed a novel small-molecule compound that is orally bioavailable and can activate KCC2 and reduce chronic pain in rats.
http://www.nature.com/nm/journal/v19/n11/abs/nm.3356.html
489 Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by loss of the translational repressor protein FMRP. Now, Joel D. Richter and his colleagues report that knocking down the expression of the translational activator protein CPEB can restore normal levels of translation and rescue behavioral deficits in a mouse model of FXS.
http://www.nature.com/nm/journal/v19/n11/abs/nm.3353.html
488 Balanced feedback loops in a receptor tyrosine kinase network control glial and neuronal differentiation in the fly eye.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/300/ra96
487 Mouse and human studies reveal that incorrect gene dosage of SHANK3 (a gene linked to some human neuropsychiatric disorders, including autism spectrum disorder) is associated with behavioural abnormalities including mania, possibly because of actin regulation problems in excitatory/inhibitory synapses.
http://www.nature.com/nature/journal/v503/n7474/full/nature12630.html
486 A neural circuit from the parabrachial nucleus to the central nucleus of the amygdala mediates appetite suppression.
http://www.nature.com/nature/journal/v503/n7474/full/nature12596.html
485 The transcription factor NPAS4 enables neurons to distinguish synaptic inputs received at their soma or dendrites; sensory stimulation increases NPAS4 which promotes inhibitory synapses on the soma and destabilizes inhibitory synapses on the dendrites.
http://www.nature.com/nature/journal/v503/n7474/full/nature12743.html
484 High-throughput imaging of neuronal activity in Caenorhabditis elegans.
http://www.pnas.org/content/110/45/E4266.abstract
483 Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma.
http://stm.sciencemag.org/content/5/209/209ra152.abstract
482 Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice.
http://www.sciencemag.org/content/342/6158/637.abstract
481 Single-cell genomics reveals that individual adult human neurons acquire diverse individual genomes.
http://www.sciencemag.org/content/342/6158/632.abstract
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