29 Direct interaction of RNA polymerase II and mediator required for transcription in vivo.
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28 Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma.
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27 Messenger RNA has received little attention as a potential therapeutic agent. Kormann et al. show that intramuscular injection of chemically modified erythropoietin mRNA substantially increases the hematocrit in mice and demonstrate the curative potential of pulmonary mRNA delivery in a mouse model of congenital surfactant protein B deficiency. Kormann SD et al. (2011). Nature Biotechnology 29: 154–157
http://www.nature.com/nbt/journal/v29/n2/abs/nbt.1733.html
26 miR-34a regulates progenitor and metastatic properties of prostate cancer cells, and they identify CD44 as a relevant target of the microRNA. The inhibition of metastasis observed after systemic delivery of miR-34a suggests that it could be used as a potential therapeutic agent in prostate cancer. Liu et al. (2011). Nature Medicine 17:211–215
http://www.nature.com/nm/journal/v17/n2/abs/nm.2284.html
25 Identification of aneuploidy-selective antiproliferation compounds.
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http://www.cell.com/abstract/S0092-8674(11)00056-0
24 Cells respond to mechanical stress by rapid disassembly of caveolae. Sinha B. et al. (2011). Cell 144: 402-413.
http://www.cell.com/abstract/S0092-8674(10)01523-0
23 Mutant proteins as cancer-specific biomarkers. Wang Q, et al. (2011). PNAS 108:2444-2449.
http://www.pnas.org/content/108/6/2444.abstract
22 Multistage nanoparticle delivery system for deep penetration into tumor tissue. Wong C. et al. (2011). PNAS 108:2426-2431.
http://www.pnas.org/content/108/6/2426.abstract
21 miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells. Kuhn S, et al. (2011). PNAS 108: 2355-2360.
http://www.pnas.org/content/108/6/2355.abstract
20 Transgenic birds expressing a short hairpin RNA that blocks viral polymerase hinder influenza transmission.
http://www.sciencemag.org/content/331/6014/223.abstract
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