127 Caspase 8 is known to suppress necroptosis, but its relevant target protein was unknown. Ting and colleagues show that caspase 8 cleaves the deubiquitylase CYLD to inhibit necroptosis and promote cell survival.
http://www.nature.com/ncb/journal/v13/n12/abs/ncb2362.html
126 Image-based genome-wide siRNA screen identifies selective autophagy factors.
http://www.nature.com/nature/journal/v480/n7375/full/nature10546.html
125 A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.
http://www.nature.com/nature/journal/v480/n7375/full/nature10539.html
124 Ras1CA overexpression in the posterior silk gland improves silk yield.
http://www.cell-research.com/201106/934.htm
123 Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe.
http://stm.sciencemag.org/content/3/110/110ra119.abstract
122 Detection of β cell death in diabetes using differentially methylated circulating DNA.
http://www.pnas.org/content/108/47/19018.abstract
121 Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/199/ra75
120 Cancer cells depend on chaperone-mediated autophagy for growth, revealing a new target for preventing tumorigenesis and inducing tumor regression.
http://stm.sciencemag.org/content/3/109/109ra117.abstract
119 A regulatory protein forms extensive interactions with the nucleosome core particle to create the basis for gene silencing.
http://www.sciencemag.org/content/334/6058/977.abstract
118 Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing.
http://www.sciencemag.org/content/334/6058/993.abstract
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