529 Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion.
http://advances.sciencemag.org/content/4/11/eaau9859
528 The authors use a machine-learning algorithm to predict the spectrum of CRISPR–Cas9-nuclease-mediated DNA repair outcomes at human genomic target sites.
https://www.nature.com/articles/s41586-018-0686-x
527 Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication.
http://www.pnas.org/content/115/48/E11311
526 Programmed DNA destruction by miniature CRISPR-Cas14 enzymes.
http://science.sciencemag.org/content/362/6416/839
525 SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.
http://science.sciencemag.org/content/362/6416/eaat9528
524 Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH.
http://stke.sciencemag.org/content/11/555/eaau7987
523 Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
https://www.nature.com/articles/s41586-018-0629-6
522 mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3.
http://www.pnas.org/content/115/43/E10069
521 An RNA-adapting CRISPR–Cas system is coupled with amplification and sequencing steps to record, retrieve and analyse changes in the transcriptome of a bacterial cell over time.
https://www.nature.com/articles/s41586-018-0569-1
520 Discovery of widespread type I and type V CRISPR-Cas inhibitors.
http://science.sciencemag.org/content/362/6411/240
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