1312 Acetate—a major gut microbial metabolite—increases the production of IgA in the colon, alters the capacity of the IgA pool to bind to specific microorganisms and alters the localization of these bacteria within the colon.
https://www.nature.com/articles/s41586-021-03727-5
1311 Telomere dysfunction instigates inflammation in inflammatory bowel disease.
https://www.pnas.org/content/118/29/e2024853118
1310 Li et al. identify LIMIT as a lncRNA that modulates MHC-I expression through HSP90 and HSF1, thereby regulating antitumour immune response and the efficacy of immunotherapy.
https://www.nature.com/articles/s41556-021-00672-3
1309 Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.
https://immunology.sciencemag.org/content/6/59/eabh2259
1308 Circulating immunity protects the female reproductive tract from Chlamydia infection.
https://www.pnas.org/content/118/21/e2104407118
1307 Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation.
https://www.sciencedirect.com/science/article/abs/pii/S1931312821001803?via%3Dihub
1306 Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice.
https://www.pnas.org/content/118/19/e2101918118
1305 Intranasal vaccination with influenza HA/GO-PEI nanoparticles provides immune protection against homo- and heterologous strains.
https://www.pnas.org/content/118/19/e2024998118
1304 CAR directs T cell adaptation to bile acids in the small intestine.
https://www.nature.com/articles/s41586-021-03421-6
1303 CD4+ T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate.
https://www.pnas.org/content/118/17/e2023172118
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