502 Short-term treatment with cytokines reprograms acinar cells into beta cells and restores durable normoglycemia in diabetic mice.
http://www.nature.com/nbt/journal/v32/n1/abs/nbt.2747.html
501 CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens.
http://www.nature.com/ni/journal/v15/n2/abs/ni.2790.html
500 High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.
http://www.nature.com/ni/journal/v15/n2/abs/ni.2784.html
499 TNF-α blockade induces IL-10 expression in human CD4+ T cells.
http://www.nature.com/ncomms/2014/140204/ncomms4199/full/ncomms4199.html
498 Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62301-6/fulltext
497 Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
http://www.nature.com/nature/journal/v505/n7485/full/nature12862.html
496 Deficiency of Innate and Acquired Immunity Caused by an IKBKB Mutation.
http://www.nejm.org/doi/full/10.1056/NEJMoa1309199
495 Vitamin A deficiency alters the balance of innate immune cells in the gut, promoting resistance to nematode infection.
http://www.sciencemag.org/content/343/6169/432.abstract
494 The intracellular sensor that triggers the death of human lymphoid CD4 T cells abortively infected with HIV is identified.
http://www.sciencemag.org/content/343/6169/428.abstract
493 Quiescent CD4 T cells in lymphoid tissues are shown to die after HIV-1 infection by caspase-1-mediated pyroptosis, a highly inflammatory form of programmed cell death; caspase 1 inhibitors, which are safe for human use, can rescue the cell death in vitro raising the possibility of new therapeutics targeting the host instead of the virus.
http://www.nature.com/nature/journal/v505/n7484/full/nature12940.html
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