419 A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.
https://www.cell.com/cell/fulltext/S0092-8674(19)31176-6
418 Correcting a protein network that regulates proteostasis reverses deficits in a mouse model of Down syndrome.
https://science.sciencemag.org/content/366/6467/843
417 The degree to which a genome can tolerate mutations is inversely correlated with the fitness of a yeast strain.
https://science.sciencemag.org/content/366/6464/490
416 Search-and-replace genome editing without double-strand breaks or donor DNA.
https://www.nature.com/articles/s41586-019-1711-4
415 The piRNA Response to Retroviral Invasion of the Koala Genome.
https://www.cell.com/cell/fulltext/S0092-8674(19)31008-6
414 An Ancient Genome from the Indus Valley Civilization.
https://www.cell.com/cell/fulltext/S0092-8674(19)31078-5
413 Polymer nanocapsules, assembled around a ribonucleoprotein complex of Cas9 nuclease and a single-guide RNA, enable safe and efficient gene editing in vitro and in vivo.
https://www.nature.com/articles/s41565-019-0539-2
412 Acoustic reporter genes enable noninvasive ultrasound imaging of gene expression in mammalian cells.
https://science.sciencemag.org/content/365/6460/1469
411 Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests.
https://science.sciencemag.org/content/365/6460/1457
410 Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.
https://science.sciencemag.org/content/365/6460/eaav7188
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