468 Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction.
https://www.pnas.org/content/116/37/18435
467 The release of tyramine during the flight response in nematodes activates the DAF-2/insulin–IGF pathway to downregulate cytoprotective mechanisms and shorten lifespan.
https://www.nature.com/articles/s41586-019-1524-5
466 Aged progenitor cells in the rat central nervous system can be made to behave as young cells by reducing the stiffness of the tissue microenvironment, or by inhibiting the mechanosensitive protein PIEZO1.
https://www.nature.com/articles/s41586-019-1484-9
465 Identification of an ATP-sensitive potassium channel in mitochondria.
https://www.nature.com/articles/s41586-019-1498-3
464 A cell-penetrating fluorescent marker is used to label cells in the metastatic tumour microenvironment, revealing a variety of cell types including parenchymal cells with lung stem-cell characteristics.
https://www.nature.com/articles/s41586-019-1487-6
463 Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes.
https://www.pnas.org/content/116/35/17239
462 High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments.
https://www.pnas.org/content/116/35/17175
461 Age Mosaicism across Multiple Scales in Adult Tissues.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30250-5
460 Building a synthetic mechanosensitive signaling pathway in compartmentalized artificial cells.
https://www.pnas.org/content/116/34/16711
459 Specialized cutaneous Schwann cells initiate pain sensation.
https://science.sciencemag.org/content/365/6454/695
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