185 Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.
http://www.pnas.org/content/110/7/2517.abstract
184 Werb and colleagues demonstrate that GATA3, a transcription factor that promotes luminal differentiation in the mammary gland, suppresses breast cancer metastasis to the lung by upregulating miR-29b. This microRNA suppresses pro-metastatic characteristics, including mesenchymal traits and the expression of microenvironmental factors involved in angiogenesis and extracellular matrix remodelling.
http://www.nature.com/ncb/journal/v15/n2/abs/ncb2672.html
183 Muthuswamy and colleagues demonstrated that loss of the Par3 polarity protein cooperates with ErbB2 activity to promote cell invasion and metastasis by destabilizing E-cadherin-dependent cell–cell junctions.
http://www.nature.com/ncb/journal/v15/n2/abs/ncb2663.html
182 Engineering a BCR-ABL–activated caspase for the selective elimination of leukemic cells.
http://www.pnas.org/content/110/6/2300.abstract
181 Drug resistance in melanomas may be overcome by therapies that trigger endoplasmic reticulum stress.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/260/ra7
180 Tumor cells circulating in the blood of cancer patients undergo a phenotypic change that may facilitate their spread.
http://www.sciencemag.org/content/339/6119/580.abstract
179 Nanoroughened Surfaces for Efficient Capture of Circulating Tumor Cells without Using Capture Antibodies.
http://pubs.acs.org/doi/abs/10.1021/nn304719q
178 Antitumor activity of a pyrrole-imidazole polyamide.
http://www.pnas.org/content/110/5/1863.abstract
177 Inhibition of triple-negative breast cancer models by combinations of antibodies to EGFR.
http://www.pnas.org/content/110/5/1815.abstract
176 Smg1 haploinsufficiency predisposes to tumor formation and inflammation.
http://www.pnas.org/content/110/4/E285.abstract
175 Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.
http://www.pnas.org/content/110/3/972.abstract
174 Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.
http://www.nature.com/nature/journal/v493/n7432/full/nature11725.html
173 Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response.
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052543
172 An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression.
http://www.cell.com/abstract/S0092-8674(12)01489-4
171 Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.
http://www.pnas.org/content/109/52/21360.abstract
170 Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
http://www.nature.com/ncb/journal/v15/n1/abs/ncb2643.html
169 Tregs that expand in human colon cancer have proinflammatory properties and contribute to tumor progression.
http://stm.sciencemag.org/content/4/164/164ra159.abstract
168 A magnetic switch for the control of cell death signalling in in vitro and in vivo systems.
http://www.nature.com/nmat/journal/v11/n12/full/nmat3430.html
167 Blocking the activation of p110β by G proteins inhibits tumor cell proliferation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/253/ra89
166 Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors.
http://www.sciencemag.org/content/338/6112/1360.abstract
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