465 TOPK inhibitor kills cancer cells by causing a cytokinesis defect and promotes tumor regression in mouse models.
http://stm.sciencemag.org/content/6/259/259ra145.abstract
464 Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin.
http://www.pnas.org/content/111/41/14687.abstract
463 ICAM-1 as a molecular target for triple negative breast cancer.
http://www.pnas.org/content/111/41/14710.abstract
462 Different mutations are present in different regions of any given lung cancer, and their pattern may predict patient relapse.
http://www.sciencemag.org/content/346/6206/256.abstract
461 Different regions of a human lung tumor harbor different mutations, possibly explaining why the disease is so tough to treat.
http://www.sciencemag.org/content/346/6206/251.abstract
460 Inhibition of Cancer Cell Proliferation by PPARγ Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00369-6
459 Bladder cancers arise from distinct urothelial sub-populations.
http://www.nature.com/ncb/journal/v16/n10/abs/ncb3038.html
458 Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.
http://www.nature.com/ncb/journal/v16/n10/abs/ncb3036.html
457 Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration.
http://stke.sciencemag.org/content/7/345/ra92.abstract
456 The growth of tumours is supported by tumour production of lactic acid, which polarizes tumour-associated macrophages to an M2 phenotype through a pathway dependent on hypoxia-inducible factor 1α.
http://www.nature.com/nature/journal/v513/n7519/full/nature13490.html
455 Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes.
http://www.pnas.org/content/111/38/13948.abstract
454 Small-molecule Bax agonists for cancer therapy.
http://www.nature.com/ncomms/2014/140917/ncomms5935/full/ncomms5935.html
453 A regulator of the enzyme that makes the building blocks of DNA provides a new target for anticancer drugs.
http://www.sciencemag.org/content/345/6203/1512.abstract
452 Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
http://www.nature.com/nature/journal/v513/n7517/full/nature13557.html
451 Comprehensive molecular characterization of gastric adenocarcinoma.
http://www.nature.com/nature/journal/v513/n7517/full/nature13480.html
450 Asymmetric triplex metallohelices with high and selective activity against cancer cells.
http://www.nature.com/nchem/journal/v6/n9/abs/nchem.2024.html
449 The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.
http://www.pnas.org/content/111/35/E3689.abstract
448 The translation of many messenger RNAs that encode important oncogenes and transcription factors depends on the eIF4A RNA helicase to resolve G-quadruplex structures, implying eIF4A inhibition as an effective cancer therapy.
http://www.nature.com/nature/journal/v513/n7516/full/nature13485.html
447 Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.
http://www.nature.com/nature/journal/v513/n7516/full/nature13528.html
446 Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality.
http://www.cell.com/cell/abstract/S0092-8674(14)00977-5
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