965 Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification
https://www.nature.com/articles/nbt.4313
964 An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma.
https://www.nature.com/articles/nbt.4302
963 Central body fatness is a stronger predictor of cancer risk than overall body size.
https://www.nature.com/articles/s41467-018-08159-w
962 Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation.
https://www.pnas.org/content/116/4/1361
961 Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody.
https://www.pnas.org/content/116/4/1370
960 IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses.
https://www.pnas.org/content/116/2/599
959 Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin.
https://www.nature.com/articles/s41586-018-0812-9
958 A large network of bacterial proteins promotes endogenous DNA damage and mutations when upregulated, acting like protein carcinogens, and has human homologs that form a cancer predictive network.
https://www.cell.com/cell/fulltext/S0092-8674(18)31622-2
957 Actively personalized vaccination trial for newly diagnosed glioblastoma.
https://www.nature.com/articles/s41586-018-0810-y
956 Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.
https://www.nature.com/articles/s41586-018-0792-9
955 De novo design of potent and selective mimics of IL-2 and IL-15.
https://www.nature.com/articles/s41586-018-0830-7
954 Deletion of the A-to-I double-stranded RNA-editing enzyme ADAR1 sensitizes tumour cells to immunotherapy.
https://www.nature.com/articles/s41586-018-0768-9
953 Organoid Modeling of the Tumor Immune Microenvironment.
https://www.cell.com/cell/fulltext/S0092-8674(18)31513-7
952 Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture.
https://www.pnas.org/content/115/50/E11671
951 Altered ubiquitination of RAS GTPases is implicated in cancer drug resistance.
http://science.sciencemag.org/content/362/6419/1171
950 Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.
http://science.sciencemag.org/content/362/6418/1055
949 Single-cell multiomics sequencing and analyses of human colorectal cancer.
http://science.sciencemag.org/content/362/6418/1060
948 Mannose impairs tumour growth and enhances chemotherapy.
https://www.nature.com/articles/s41586-018-0729-3
947 Cancer-associated mutations are surprisingly common in normal esophageal epithelium from human donors.
http://science.sciencemag.org/content/362/6417/911
946 Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.
http://www.pnas.org/content/115/47/E11091
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