1035 Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
https://www.cell.com/cell/fulltext/S0092-8674(19)30630-0
1034 A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.
https://www.cell.com/cell/fulltext/S0092-8674(19)30556-2
1033 Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer.
https://www.cell.com/cell/fulltext/S0092-8674(19)30510-0
1032 Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy.
https://stm.sciencemag.org/content/11/498/eaaw2614
1031 An analysis of more than 2500 human tumors reveals that cancer driver and passenger mutations can be identified from mesoscale genomic context.
https://science.sciencemag.org/content/364/6447/eaaw2872
1030 A Mucin 16 bispecific T cell–engaging antibody for the treatment of ovarian cancer.
https://stm.sciencemag.org/content/11/497/eaau7534
1029 The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
https://science.sciencemag.org/content/364/6446/1156
1028 A new anti-CD19 CAR T cell therapy induces potent antitumor responses without causing severe cytokine-release syndrome or neurotoxicity in patients with lymphoma.
https://www.nature.com/articles/s41591-019-0421-7
1027 Genome-wide cell-free DNA fragmentation in patients with cancer.
https://www.nature.com/articles/s41586-019-1272-6
1026 In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma.
https://stm.sciencemag.org/content/11/496/eaat5857
1025 Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
https://stm.sciencemag.org/content/11/496/eaav5989
1024 Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies.
https://www.pnas.org/content/116/24/11978
1023 Perfluorocarbon nanoparticle-mediated platelet inhibition promotes intratumoral infiltration of T cells and boosts immunotherapy.
https://www.pnas.org/content/116/24/11972
1022 Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy.
https://www.nature.com/articles/s41586-019-1215-2
1021 Genomic correlates of clinical outcome in advanced prostate cancer.
https://www.pnas.org/content/116/23/11428
1020 Aneuploidy drives lethal progression in prostate cancer.
https://www.pnas.org/content/116/23/11390
1019 Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
https://www.nature.com/articles/s41586-019-1173-8
1018 Progenitors from the central nervous system drive neurogenesis in cancer.
https://www.nature.com/articles/s41586-019-1219-y
1017 Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.
https://www.nature.com/articles/s41591-019-0423-5
1016 Preventable Cancer Burden Associated with Poor Diet in the United States.
https://academic.oup.com/jncics/advance-article/doi/10.1093/jncics/pkz034/5492023?searchresult=1
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