997 Exogenous pyruvate is needed for breast cancer cells to form metastases, and the inhibition of pyruvate metabolism impairs collagen hydroxylation and the growth of lung metastases in different mouse models.
https://www.nature.com/articles/s41586-019-0977-x
996 Deprivation of glutamine in cell culture reveals its potential for treating cancer.
https://www.pnas.org/content/116/14/6964
995 GPRC5D is an attractive target for immunotherapy of myeloma, and optimized GPRC5D-targeted CAR T cells eradicate myeloma xenografts.
http://stm.sciencemag.org/content/11/485/eaau7746
994 T cell stemness and dysfunction in tumors are triggered by a common mechanism.
http://science.sciencemag.org/content/363/6434/eaau0135
993 NR4A transcription factors limit CAR T cell function in solid tumours.
https://www.nature.com/articles/s41586-019-0985-x
992 Glucocorticoids promote breast cancer metastasis.
https://www.nature.com/articles/s41586-019-1019-4
991 A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy.
https://www.nature.com/articles/s41551-019-0363-x
990 A Highly Efficient Tumor‐Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism.
https://onlinelibrary.wiley.com/doi/10.1002/adma.201807456
989 Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.
https://www.nature.com/articles/s41586-019-0993-x
988 An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma.
http://stm.sciencemag.org/content/11/483/eaau9732
987 Mutations that protect a small guanosine triphosphatase from its normal proteolytic degradation lead to excessive growth factor signaling.
http://science.sciencemag.org/content/363/6432/1226
986 Pancreatic cancer activates IL-6–STAT3 signalling in hepatocytes to induce the formation of a pro-metastatic niche in the liver.
https://www.nature.com/articles/s41586-019-1004-y
985 Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
http://stm.sciencemag.org/content/11/482/eaau5612
984 The authors find that loss of squalene monooxygenase expression alters the lipid metabolism of cancer cells, which confers protection from ferroptotic cell death and thus promotes tumour growth.
https://www.nature.com/articles/s41586-019-0945-5
983 Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.
https://www.pnas.org/content/116/10/4558
982 The authors show that circulating tumour cells can be found in association with neutrophils, an interaction which supports their proliferation and their ability to seed metastasis.
https://www.nature.com/articles/s41586-019-0915-y
981 The progression of colorectal cancer is fueled by the bile-acid-dependent inhibition of the receptor FXR.
https://www.cell.com/cell/fulltext/S0092-8674(19)30099-6
980 Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
https://www.cell.com/cell/fulltext/S0092-8674(18)31654-4
979 Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways.
https://www.pnas.org/content/116/9/3909
978 Infiltration of CD8+ T cells into tumor cell clusters in triple-negative breast cancer.
https://www.pnas.org/content/116/9/3678
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