1034 A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.
https://www.cell.com/cell/fulltext/S0092-8674(19)30556-2
1033 Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer.
https://www.cell.com/cell/fulltext/S0092-8674(19)30510-0
1032 Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy.
https://stm.sciencemag.org/content/11/498/eaaw2614
1031 An analysis of more than 2500 human tumors reveals that cancer driver and passenger mutations can be identified from mesoscale genomic context.
https://science.sciencemag.org/content/364/6447/eaaw2872
1030 A Mucin 16 bispecific T cell–engaging antibody for the treatment of ovarian cancer.
https://stm.sciencemag.org/content/11/497/eaau7534
1029 The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
https://science.sciencemag.org/content/364/6446/1156
1028 A new anti-CD19 CAR T cell therapy induces potent antitumor responses without causing severe cytokine-release syndrome or neurotoxicity in patients with lymphoma.
https://www.nature.com/articles/s41591-019-0421-7
1027 Genome-wide cell-free DNA fragmentation in patients with cancer.
https://www.nature.com/articles/s41586-019-1272-6
1026 In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma.
https://stm.sciencemag.org/content/11/496/eaat5857
1025 Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
https://stm.sciencemag.org/content/11/496/eaav5989
1024 Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies.
https://www.pnas.org/content/116/24/11978
1023 Perfluorocarbon nanoparticle-mediated platelet inhibition promotes intratumoral infiltration of T cells and boosts immunotherapy.
https://www.pnas.org/content/116/24/11972
1022 Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy.
https://www.nature.com/articles/s41586-019-1215-2
1021 Genomic correlates of clinical outcome in advanced prostate cancer.
https://www.pnas.org/content/116/23/11428
1020 Aneuploidy drives lethal progression in prostate cancer.
https://www.pnas.org/content/116/23/11390
1019 Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
https://www.nature.com/articles/s41586-019-1173-8
1018 Progenitors from the central nervous system drive neurogenesis in cancer.
https://www.nature.com/articles/s41586-019-1219-y
1017 Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.
https://www.nature.com/articles/s41591-019-0423-5
1016 Preventable Cancer Burden Associated with Poor Diet in the United States.
https://academic.oup.com/jncics/advance-article/doi/10.1093/jncics/pkz034/5492023?searchresult=1
1015 Patient data from six clinical trials are used to compare the genomic landscapes of breast cancer metastases with those of primary tumours, revealing an increase in mutational burden and clonal diversity.
https://www.nature.com/articles/s41586-019-1056-z
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