1025 Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
https://stm.sciencemag.org/content/11/496/eaav5989
1024 Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies.
https://www.pnas.org/content/116/24/11978
1023 Perfluorocarbon nanoparticle-mediated platelet inhibition promotes intratumoral infiltration of T cells and boosts immunotherapy.
https://www.pnas.org/content/116/24/11972
1022 Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy.
https://www.nature.com/articles/s41586-019-1215-2
1021 Genomic correlates of clinical outcome in advanced prostate cancer.
https://www.pnas.org/content/116/23/11428
1020 Aneuploidy drives lethal progression in prostate cancer.
https://www.pnas.org/content/116/23/11390
1019 Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
https://www.nature.com/articles/s41586-019-1173-8
1018 Progenitors from the central nervous system drive neurogenesis in cancer.
https://www.nature.com/articles/s41586-019-1219-y
1017 Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.
https://www.nature.com/articles/s41591-019-0423-5
1016 Preventable Cancer Burden Associated with Poor Diet in the United States.
https://academic.oup.com/jncics/advance-article/doi/10.1093/jncics/pkz034/5492023?searchresult=1
1015 Patient data from six clinical trials are used to compare the genomic landscapes of breast cancer metastases with those of primary tumours, revealing an increase in mutational burden and clonal diversity.
https://www.nature.com/articles/s41586-019-1056-z
1014 Next-generation characterization of the Cancer Cell Line Encyclopedia.
https://www.nature.com/articles/s41586-019-1186-3
1013 PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.
https://www.pnas.org/content/116/20/9999
1012 Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
https://science.sciencemag.org/content/364/6441/eaau0159
1011 Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.
https://www.cell.com/cell/fulltext/S0092-8674(19)30292-2
1010 ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
https://www.nature.com/articles/s41556-019-0305-6
1009 Engineered immune cells as highly sensitive cancer diagnostics.
https://www.nature.com/articles/s41587-019-0064-8
1008 Interferon-γ induces ferroptotic cell death in tumours by suppressing cystine uptake and promoting lipid peroxidation.
https://www.nature.com/articles/s41586-019-1170-y
1007 Effective PD-1 immunotherapy is influenced by the intensity of tumor microsatellite instability.
https://science.sciencemag.org/content/364/6439/485
1006 In a screen of 324 human cancer cell lines and utilising a systematic target prioritization framework, the Werner syndrome ATP-dependent helicase is shown to be a synthetic lethal target in tumours from multiple cancer types with microsatellite instability, providing a new target for cancer drug development.
https://www.nature.com/articles/s41586-019-1103-9
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