1057 Proper dosing and timing of EGFR TKI can trigger antitumor T cell responses and potentiate anti–PD-L1 immunotherapy.
https://immunology.sciencemag.org/content/4/38/eaav6473
1056 Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling.
https://www.nature.com/articles/s41586-019-1426-6
1055 Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
https://www.nature.com/articles/s41586-019-1437-3
1054 CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
https://www.nature.com/articles/s41586-019-1456-0
1053 A tumor-targeted immune checkpoint blocker.
https://www.pnas.org/content/116/32/15889
1052 Resolving medulloblastoma cellular architecture by single-cell genomics.
https://www.nature.com/articles/s41586-019-1434-6
1051 Flower isoforms promote competitive growth in cancer.
https://www.nature.com/articles/s41586-019-1429-3
1050 CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.
https://www.pnas.org/content/116/31/15635
1049 Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers.
https://www.pnas.org/content/116/31/15524
1048 Engineering nanoparticles to locally activate T cells in the tumor microenvironment.
https://immunology.sciencemag.org/content/4/37/eaau6584
1047 Antioxidants stimulate lung cancer metastasis by reducing free heme levels and stabilizing the transcription factor BACH1.
https://www.cell.com/cell/fulltext/S0092-8674(19)30633-6
1046 The immune response is modulated at a early stage of carcinogenesis, such that both immune activation and evasion precede tumour invasion.
https://www.nature.com/articles/s41586-019-1330-0
1045 Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
https://www.cell.com/cell/fulltext/S0092-8674(19)30631-2
1044 Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function
https://stke.sciencemag.org/content/12/590/eaaw7095
1043 Engineering nanoparticles to locally activate T cells in the tumor microenvironment.
https://immunology.sciencemag.org/content/4/37/eaau6584
1042 Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor.
https://science.sciencemag.org/content/365/6449/162
1041 Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix.
https://www.pnas.org/content/116/28/14181
1040 dTcf/Pangolin suppresses growth and tumor formation in Drosophila.
https://www.pnas.org/content/116/28/14055
1039 UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.
https://www.nature.com/articles/s41586-019-1340-y
1038 Programmable bacteria induce durable tumor regression and systemic antitumor immunity.
https://www.nature.com/articles/s41591-019-0498-z
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